One of the claims made by anti-multi level marketing bloggers against Protandim is Dr McCord isn’t the inventor of Protandim. This statement is made to make it appear that Protandim is ineffectual and the company is dishonest. Here is how Protandim was created:
Paul MyHill was a partner in a nutraceutical company called Lifeline Therapeutics. He and his colleagues hired a biotech firm to produce a synthetic of Superoxide Dismutase (really a Nrf2 activator that regulates SOD). The product called CMX-1152 was shown to not work, in fact I understand it was also harmful (as are many synthetic drugs). In attempt to salvage the business, Paul MyHill (who admittedly doesn’t have a science or medical degree), began researching SOD, and natural approaches instead of synthetics, and identified plants who’s properties had been proven to regulate SOD in the body. In his research he found dozens of herbs (and the list was extensive) that activated Nrf2 and could potentially increase SOD production naturally in the body. In the process of his research, Paul found the man who discovered SOD (some 35 years prior), Dr Joe McCord was also located in Colorado, at the University of Denver Colorado as a professor of medicine. Paul sought to speak with Dr Joe McCord to get some feedback on his concepts, and see if Dr McCord would be willing to validate his concepts.
At their visit, Dr McCord told Paul he didn’t think it would work, that “herbs are not powerful enough”. For some reason however, McCord who was seemingly interested, looked closer at Paul’s concepts and the two began working together. Paul had already identified the key ingredients in Protandim, and began to file a patent. On several occasions he discussed with McCord, on him being involved on the patent. As I understand, after several months of collaboration and experiments and small alterations from McCord, Protandim as we know it was formulated, and the final patent was accepted by the US government. Because of his background, McCord had the ability to measure Protandim’s effectiveness and his participation on the final formula was critical. If it wasn’t for years of experiments McCord had conducted prior, his understanding of free radical biology and SOD and Nrf2 activation, McCord wouldn’t know how or what to look for, let alone assist Paul in the final changes to Paul’s concept.
After some small alterations to the formula, McCord was able to successfully validate that Protandim “worked”, when taken by people, the level of oxidative stress (as measured by TBARS) was reduced to the level of a child. This formula was proven to be 18 times more powerful than any 1 ingredient, the synergy of the 5 was “powerful enough”, despite McCords initial reaction. Further research conducted by McCord (peer reviewed) showed it did so by activating Nrf2, up-regulating SOD, Catalase and other enzymes that are powerful anti-oxidants made in the body. In fact, third party review shows Protandim is a more powerful inducer of Nrf2 than even the latest Nrf2 drug activators. In one of these reviews, a head to head comparison of the 4 known Nrf2 activators, Protandim, the two pharmaceutical products bardoxolone (www.reatapharma.com) and BG12 (www.biogenidec.com) and sulforaphane (the ingredient in broccoli) that Protandim was twice as potent as either bardoxolone or BG-12 and was 7 times as potent as sulforaphane as a Nrf2 activator.
The company Paul worked for (Lifeline Nutraceuticals) , did a reverse merger with LifeLine Theraputics, a public traded company to later be renamed LifeVantage. This product was given the name Protandim, a name early company owners had created before the herbal product was formulated. In a letter sent by Dr McCord to Paul, Dr McCord indicated he was not interested in being on the Patent after many previous discussions (and likely invitations) to be on the patent. However Dr McCord indicated his interest was to pursue research with Protandim. The timing of this letter imply’s two things not often mentioned. First, the patent was not finalized before McCords involvement. Second, McCord turns down the invite to pursue more research including Protandim and the science and effective of it. LifeVantage later hired McCord to be on the board of directors as a scientific adviser. It’s also interesting to note that, with hundreds of hours of research and product development with Paul, McCord was awarded stock in the young LifeVantage company.
Another note, after the run up of the stock a short few months later, Paul resigns from the company to pursue his charity work, which he continues today. Dr McCord was left the only surviving member from the Protandim genesis, then hired on by LifeLine Therapeutics as a board member. LifeLine Therapeutics was later renamed LifeVantage a year later. I think this is largely why LifeVantage had McCord be the spokesperson for Protandim’s “invention”, due to the absence of Paul MyHill.
Interestingly, Dr. McCord and Dr. Crapo from National Jewish Medical Center (shown in the ABC Primetime Video on Protandim) both abandoned their efforts with synthetic compounds when they found this synergistic effect of the 5 ingredients in Protandim. Everything since has been validating as Protandim research continues. Most of these studies have been paid for completely outside of LifeVantage, and while McCord was a co-author on most (not all), they’re all peer reviewed, and published in science and medical journals. These journals had access to all the same information, but found value in publishing the research.
Today the patents are all owned by LifeVantage (have for years). The inventor still shows Paul MyHill, because each subsequent patent uses the name of the inventor as published on the first patent.
Paul said on his Facebook page the following:
“I love Protandim and LifeVantage. They are indeed “my babies” and a great part of my legacy. They have changed my life and the lives of thousands around the world. I think the current management team and distribution model are excellent. All the distributors I have met or talked to are simply amazing. As David Brown mentioned at Elite in San Antonio, this is the embodiment of my original vision for the company and product.
“I also need to say that there are not “two sides to the story” as far as the development of Protandim is concerned. There is only one story – and it honors my involvement and Joe’s involvement, plus the involvement of the One who was ultimately responsible.
“Nobody lied. Nobody covered anything up. Sure, there have been some misspoken words, media/reporter errors, and some confusion over terminology: inventor versus formulator; creator versus developer, etc., but this has been because we are simply human and not perfect, because we were treading into uncharted territory with the development of this game-changing product, and because we went through quite a few management team changes until we were blessed with this one. I take my fair share of the blame for the confusion caused along the way, and for not remaining engaged with LifeVantage during those dry years.
“Please don’t let the naysayers and critics dissuade you. This is an excellent company with an excellent product and excellent folks involved at all levels. I’m very proud of my involvement in the past, present and future.
. . . And that future looks incredibly bright!”
Yes, without Paul MyHill, Protandim would not exist, because his concepts brought to McCord were vital. But without McCord Protandim would likely not exist either, because Paul found McCord’s contributions and history critical to its final formulation, continued research and ultimate success. Paul left LifeVantage many years ago and sold much (if not all) of the stock he owned to further his interests in his orphan fund. Since, McCord has increasingly become more involved at LifeVantage on the Science advisory board. The company has not “hidden” Paul’s involvement (see the video from David Brown linked below). Paul simply had not been a member of the company for a long time. And if we’re honest, McCords involvement in the research and his history in free radical biology, the discovery of SOD, makes him a very good spokesperson for the science behind Protandim, especially considering Paul’s absence.
Read some of a radio interview with Paul a few years ago here: http://www.blogtalkradio.com/lifevantage/blog/2009/03/09/inside-protandim-the-paul-myhill-interview
Also David Brown talks about the history of Protandim here: http://www.lifevantage.com/video-player.aspx?key=cS2Ukvdm and I recommend that anybody who wants a well rounded view of this watch it.
Read some of Protandim’s history here: (the site is outdated since it became a network marketing company) http://tonyc.com/protandim/
Other interesting notes: http://www.raysahelian.com/protandim.html
In an attempt to keep this information as accurate as possible, I will make modifications to this if I have made any mistakes. Replies are always welcome.